نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشکده شیلات / دانشگاه آزاد اسلامی واحد بابل / بابل / ایران
2 هیات علمی دانشگاه آزاد اسلامی واحد بابل
3 هیات علمی دانشگاه تمپرره فنلاند
4 هیات علمی دانشگاه علوم پزشکی تهران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
In this study, zebrafish was used as a biological model to induce type 2 diabetes mellitus through glucose.
Then, the effect of metformin and silibinin combination was examined on elevated blood glucose and intestinal tissues. Intestine tissue staining performed by hematoxylin and eosin protocol (H and E).
The combination of these two drugs had also a significant role in reducing glucose levels.
The body weight increased significantly in the control group which was affected by glucose concentration, with the lowest body weight gain observed in the metformin group.
Diabetic state causes weak absorption whereby the fish body demands to increase absorption level by enhancing the amount of acidic goblet cells thereby acidifying the environment in the gastric tracts.
Collectively, this study indicated that treatment with metformin and Silibinin could improve metabolic mediated performances by reducing the blood glucose, and ameliorating the intestinal inflammation in type 2 diabetic zebrafish model. .
کلیدواژهها [English]