Antioxidant effect of aqueous extract of cinnamon in pancreatic tissue of streptozotocin-induced diabetic male rats

Document Type : Physiology (Animal)

Authors

1 biology department, faculty of science, Urmia University, Urmia, Iran

2 Biology department, faculty of science, Urmia University, Urmia, Iran

3 Artemia and Aquatics Research institute, Urmia University, Urmia, Iran

4 Department of biology, faculty of science, Urmia University, Urmia, Iran

Abstract

Diabetes is the most common metabolic disease in the world. Diabetic Complications, oxidative stress induced by free radicals linked.Body's antioxidant defense mechanisms to fight through it arise. Parameters reduction of glucose control and serum lipids in patients with the use of medicinal plants is important. The aim of this study was to evaluate the antioxidant effect of the aqueous extract of cinnamon on pancreatic tissue of streptozotocin-induced diabetic male rats. In this study, the diabetes induced in 21 adult male Wistar rats in the weight range 200 ± 30 with an intra-peritoneal injection of streptozotocin (mg/kg 50). Animals in three groups of  7 digits healthy, diabetic control and diabetic rats treated with the extract, respectively. Fasting mice were injected with a dose of 50 mg/kg of streptozotocin (STZ) intraperitoneally was diabetic. After 21 days of treatment with the extract at a dose of 200 mg / kg of malondialdehyde (MDA), FRAP and catalase were measured in three groups of pancreatic tissue. In order to perform statistical analyzes were performed using SPSS software. All data are presented as mean ± standard error (SE ± Mean) was expressed. ANOVA test and the Tukey's test were used for comparisons between groups. Significant in statistical work (0.05> P) was considered. The results showed that treatment with cinnamon extract increases the FRAP and MDA decreased in male rats, but in this study the changes in catalase activity was observed.

Keywords

Journal of Animal Environment
Volume 7, Issue 3 - Serial Number 3
November 2015
Pages 57-64

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