The Effects of Zygophyllum eurypterum on the Cutaneous Wound Healing in the Mouse (Mus musculus)

Document Type : Physiology (Animal)

Authors

1 Departement of Biology, Emam Mohammad Bagher Research Center, Rafsanjan, Iran.

2 Department of Biology, Farhangian University, Kerman, Iran

3 Department of Physiology, University of medical sciences, Rafsanjan, Iran

Abstract

To date, an effective and exact chemical drug has not been introduced for wound healing acceleration. Therefore the use of herbal medicine studies, are performed. In this study we compared the leaves dough and water extract of the Ghich (Zygophyllum eurypterum: Zygophylaceae) with Phenytoin cream 1% on the skin wound healing rate in the male souri mouse (Mus musculus). This experimental study was performed on the six groups of male mice. After mice anesthetizing, the skin lesion area with7/85 mm2 was created on the animal back. From the first day, phenytoin cream 1%, leaves dough and water extract (in 3 doses: 50, 100, 200) were applied on the wound. The wound surface every day and the percentage of wound healing in 3th, 6th, 9th, 12th and 14th  days were measured.  Also the time needed for complete wound healing was determined. The results showed that the percentage of wound healing in leaf dough and water extract (100) groups was higher than the ointment group (P <0/001). The required time for complete wound healing was significantly lower in dough leaves and water extract (100) compared to the Phenytoin and control groups (P < 0.001). The leaf and water extract of Zygophyllum eurypterum rises the cutaneous wound healing. 

Keywords

Journal of Animal Environment
Volume 7, Issue 3 - Serial Number 3
November 2015
Pages 65-72

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