The effect of administration of hydroethanolic extract of marigold (Calendula officinalis) on serum glucose, serum lipids and liver enzymes AST, ALT in male diabetic Wistar rats

Document Type : Physiology (Animal)

Authors

1 Faculty of Pharmacy, Haman University of Medical Sciences

2 Department of Anesthesiology, School of Medicine, Hamedan University of Medical Sciences

3 Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamedan University of Medical Sciences

Abstract

Diabetes millitus is a common metabolic disorder due to dysfunctional insulin secretion and hyperglycemia. The main aim of this study is to investigate the effect of hydroethanolic extract of marigold (Calendula officinalis) on glucose, serum lipids and liver enzymes of AST, ALT in diabetic male Wistar rats.
This research is an experimental-laboratory study on male Wistar rats (n=32) weighing 180-200 gr. The Rats were randomly divided into 4 groups, including normal control,extract treated- normal  control, diabetic control and extract- treated diabetic rats.A single intraperitoneal dose  of (60mg/kg) STZ was used to induce experimental diabetes in the rats.The Extract was given orally (300mg/kg.P.O) to diabetic rats and the other group took normal salin at the same time.At the end of the eight- week treatment , blood samples were collected dirvectly from heart and then biochemical tests of liver enzymes , serum lipids and glucose were done.The collected data was analyzed using ANOVA and SPSS20. The obtained results indicated that serum levels of liver enzymes i.e. AST , ALT, and cholesterol and triglycerdices were significantly reduced in treatment groups compared to diabetic control group (p<0.05).The finding revealed that administration of hydroethanolic extract of marigold can significantly decrease serum leves of liver enzymes , glucose and serum lipids through Anthocynanins like licopene , saponin , carotene. It also reduces antioxidant and flavonoids effects of this extract in diabetic rats significantly (p<0.05). 

Keywords

Journal of Animal Environment
Volume 7, Issue 3 - Serial Number 3
November 2015
Pages 73-80

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