Different levels study of Milk thistle herb and Cotrimoxazole antibiotic on blood metabolites of Ross broilers

Document Type : Physiology (Animal)

Author

Department of Animal Science, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

Abstract

Milk thistle plants including medicinal plants useful that its extract has antioxidant and liver protection. The aim of this study was to investigate the effect of different levels of Milk thistle herb and antibiotics Cotrimoxazole on blood metabolites of Ross broilers. In this experiment, milk thistle herb in three levels 0, 0.3 and 3 percent and antibiotics Cotrimoxazole in two levels 0 and 2 kg with 3 repeat were considered. Blood metabolites were measured at 42 days of age. Metabolites include glucose, cholesterol, prothrombin time (PT), uric acid, creatinine and bilirubin. Data to evaluate the effect of factors under study using the general linear model (GLM) and SAS statistical software were analyzed. Antibiotic cotrimoxazole was a significant effect on blood glucose (p<0.05). Milk thistle effect was a significant on blood cholesterol (p<0.05) and Cotrimoxazole antibiotic effect on blood cholesterol was a very significant (p<0.01). Milk thistle effect on uric acid and creatinine levels was a significant (p<0.05). The different levels of Milk thistle was very significant on bilirubin in the blood (p<0.01). Different between mean of Milk thistle and antibiotic cotrimoxazole for prothrombin time (PT) was significant (p<0.05). Use of the Milk thistle levels reduced the liver problems, because the amounts of liver enzymes secreted in the blood was decreased. Level 3% Milk thistle have maximum protective effect on the liver.

Keywords


  1. Alcicek, A.; Bozkurt, M. and Cabuk, M., 2003. The effect of an essential oil combination derived from selected herbs growing wild in Turkey on broiler performance. South African Journal of Animal Science. Vol. 33, No. 2,
    pp: 89-94.
  2. Hernandez, F.; Madrid, J.; Garcia, V.; Orengo, J. and Megias, M.D., 2004. Influence of two plants extracts on broiler performance, digestibility and digestive organ size. Poultry Science. Vol. 83, pp: 169-174.
  3. Kalorey, D.R.; kurkure, N.V.; Ramgaonkar, I.S.; Sakhare, P.S.; Warke, S. and Nigot, N.K., 2005. Effect of polyherbal feed supplement Growell during induced aflatoxicosis, ochratoxicosis and combined mycotoxicoses in broilers. Poultry Science. Vol. 65, No. 12, pp: 2239-2245.
  4. National Research Council. 1994. Nutrient Requirements of poultry, 9th rev. ed. National Academy press, Washington DC.
  5. Radco, L. and Cybulski, W., 2007. Application of silymarin in humam and animal medicine. Wounds A Compendium of Clinical Research and Practice. Vol. 1, No. 1, pp: 22-26.
  6. Schiavone, A.; Righi, F.; Quarantelli, A.; Bruni, R.; Serventi, P. and Fusari, A., 2007. Use of Silybum marianum fruit extract in broiler chicken nutrition: influence on performance and meat quality. Journal of Animal Physiology and Animal Nutrition. Vol. 91, pp: 256-262.
  7. Sobolova, L.; Skottova, N.; Vecera, R. and Urbanek, K., 2006. Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. Pharmacological Research. Vol. 53, pp: 104-112.
  8. Tedesco, D.; Steidler, S.; Galletti, S.; Tameni, M.; Sonzogni, O. and Ravarotto, L., 2004. Efficacy of Silymarin-Phospholipid Complex in Reducing the Toxicity of Aflatoxin B1 in Broiler Chicks. Poultry Science. Vol. 83, pp: 1839-1843.
  9. Tyler, V., 1993. The Honest Herbal. Binghamton, N. Y: Pharmaceutical Products.
  10. Vogel, G.; Trost, W. and Brraatz, R., 1975. Pharmacodynamics, site and mechanism of action Silybum marianum (L.) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) Pharmacology. Arzneimittel-Forschung-Drug Research. Vol. 25, No. 1, pp: 82-89.
  11. SAS Institute. 1999. SAS User’s Guide. SAS Inst. Inc., Cary, NC.