عنوان مقاله [English]
Metal oxide nanoparticles are among the most widely used compounds among nanoparticles that have wide applications in various fields. Nanoparticles have high chemical and biological reactivity by increasing their surface to volume ratio, which leads to increased production of free radicals. The generated free radicals disrupt the oxidation state and normal regeneration of body cells and cause oxidative damage in organisms and many diseases. The aim of this study was to investigate the oxidant effect of nickel oxide nanoparticles and also the antioxidant effect of chitosan-alginate nanoparticles in the model alginate model The fish is goldfish. Accordingly, in this study, 5 groups of fish were used for experiments with 4-week treatments. The study groups included the control group, the treatment group with nickel oxide nanoparticles and 3 groups of simultaneous treatment of nickel oxide nanoparticles and alginate-chitosan nanoparticles containing curcumin. At the end of the period, liver samples were isolated and collected for oxidative damage. Total antioxidant levels, MDA, glutathione and the antioxidant enzymes catalase, glutathione S-transferase and superoxide dismutase were measured in all groups. The results showed that treatment with nickel oxide nanoparticles decreased the level of total antioxidants and increased the level of MDA in the nickel oxide nanoparticle treatment group, but the groups that received curcumin-containing alginate-chitosan nanoparticles along with nickel oxide nanoparticles had anti-oxidant parameters. They gave. These results showed strong evidence of induction of cellular oxidative stress due to exposure to nickel oxide nanoparticles as well as the protective effect of curcumin-containing alginate-chitosan nanoparticles.