بررسی تاثیر منابع مختلف سلنیوم بر روی برخی از عناصر معدنی و آنتی اکسیدان‌های خون بره‌های کبوده فارس

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه علوم دامی، واحد داراب، دانشگاه آزاد اسلامی، داراب، ایران

2 گروه علوم دام، پردیس کشاورزی و منابع طبیعی، دانشگاه تهران، کرج، ایران

10.22034/AEJ.2021.307195.2648

چکیده

سلنیوم یک عنصر کمیاب ضروری برای بسیاری از فرایندهای فیزیولوژیکی، به ویژه برای عملکرد سیستم‌های ایمنی و تولید مثل، متابولیسم هورمون‌های تیروئید و هم چنین دفاع آنتی‌اکسیدانی است. این مطالعه به منظور بررسی منابع مختلف سلنیوم روی برخی از عناصر معدنی و آنتی اکسیدان های خون بره‌های کبوده فارس انجام گرفت. در این آزمایش از تعداد 16 راس بره نژاد کبوده فارس 4 ماهه با متوسط وزن 2±35 کیلوگرم استفاده گردید. در آغاز این پژوهش بره‌های مورد استفاده از ابتدا پلاک‌کوبی، وزن‌شان ثبت و تحت معاینه بالینی قرار گرفتند. تیمارهای مورد آزمایش شامل سلنیت سدیم و نانوسلنیوم به صورت خوراکی به میزان یک دهم میلی‌گرم به ازائ هر کیلوگرم وزن بدن به مدت ده روز، ویتامین ای سلنیوم (به صورت تزریقی به میزان 005/ 0 میلی‌گرم به ازای هر کیلوگرم وزن زنده) و گروه شاهد (فاقد  سلنیوم) بودند. آب و نمک به صورت آزاد در اختیار دام‌ها قرار گرفت.  جیره پایه براساس احتیاج نژادی و خوراک دهی به‌صورت دو بار در روز (ساعات 8:00 صبح و 18:00 غروب) انجام شد. مدت  آزمایش 30 روز و نمونه‌گیری از خون بره‌ها در روزهای شروع آزمایش (صفر)، 10 و 30 روزگی به عمل آمد. غلظت عناصر آهن، مس و روی تحت تاثیر منابع مختلف سلنیوم تفاوت معنی‌داری را نشان داد (0/05>P). به‌طورکلی استفاده از منابع مختلف سلنیوم موجب کاهش غلظت آهن، مس و افزایش غلظت روی پلاسما در دوره های مختلف آزمایش شد. سلنیوم خون بره‌ها در طی آزمایش نیز با یکدیگر اختلاف معنی‌داری نشان داد (0/05>P) و میزان آن در طی آزمایش افزایش یافت. فعالیت آنزیم گلوتاتیون پراکسیداز و سوپراکسیدودیسموتاز نیز تحت تاثیر منابع مختلف سلنیوم افزایش یافت (0/05>P). به‌طور کلی استفاده از منابع مختلف سلنیوم موجب کاهش غلظت آهن و مس سرم در دوره های اول، دوم و سوم گردید و غلظت روی نیز در دوره‌های مختلف آزمایش افزایش معنی‌داری را نشان داد. سلنیوم با افزایش بیان رسپتورهای ترانسفرین در سطح سلول‌های بافت‌ها، ورود ترانسفرین به داخل سلول را به روش اندوسیتوز با واسطه گیرنده افزایش داده و این امر موجب کاهش غلظت آهن سرم می‌گردد. از طرفی کاهش آهن بر ساخت سرولوپلاسمین تاثیر داشته و این پروتئین، وظیفه انتقال مس را بر عهده دارد. تغییرات مس ممکن است یک اثر غیر مستقیم بر غلظت روی سرم داشته باشد. جذب روی درسطح روده توسط مس از طریق افزایش سنتز متالوتیونین، اختلال پیدا می‌کند. استفاده از منابع مختلف سلنیوم سبب تامین مداوم عنصر سلنیوم و به حد مطلوب رسیدن غلظت سلنیوم پلاسما شد. افزایش سطح آنزیم گلوتاتیون پراکسیداز به دلیل، ارتباط مستقیم بین غلظت سلنیوم و فعالیت گلوتاتیون پراکسیداز است. به‌طورکلی استفاده از سلنیوم سبب عملکرد بهینه بره‌ها و سلامتی آن‌ها را بهبود می‌بخشد.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Investigation on the Effect of Different Selenium Sources on Some Mineral Elements and Antioxidants in the Blood of Fars kaboodeh Lambs

نویسندگان [English]

  • Ebrahim Talebi 1
  • Aziz Dolatkhah 1
  • Reza Asadi Moghadam 2
1 Department of Anima Sciences, Darab Branch, Islamic Azad University, Darab, Iran
2 Department of Animal Science, Agriculture and Natural Resources Campus, University of Tehran, Karaj, Iran
چکیده [English]

Selenium is an essential trace element for many physiological processes, especially for the functioning of the immune and reproductive systems, the metabolism of thyroid hormones, and antioxidant defense. This study was performed to investigate different sources of selenium on some mineral elements and antioxidants in the blood of Fars kaboodeh lambs. In this experiment, sixteen 4-month-old Fars kaboodeh lambs with an average weight of 35±2 kg were used. At the beginning of this study, the lambs used for plaque were first weighed and subjected to clinical examination. The treatments tested included sodium selenite and nano-selenium orally at the rate of one-tenth of a milligram per kilogram of body weight for ten days, vitamin E selenium (injectable at a rate of 0.005 mg per kilogram of live weight), and the control group (without selenium). Water and salt were provided ad libitum to the animals. The basic diet was performed twice a day (8:00 am and 6:00 pm) based on racial needs and feeding. The duration of the experiment was 30 days and blood sampling of lambs was performed on the days of the experiment (zero), 10 and 30 days. The concentrations of iron, copper and zinc under the influence of different sources of selenium showed a significant difference (P<0.05). In general, the use of different sources of selenium decreased the concentration of iron, copper and increased the concentration of plasma in different periods of the experiment. Blood selenium of lambs during the experiment also showed a significant difference (P<0.05) and its amount increased during the experiment. The activity of glutathione peroxidase and superoxide dismutase also increased under the influence of different sources of selenium (P<0.05). In general, the use of different sources of selenium decreased the concentration of iron and copper in serum in the 1st, 2nd, and 3rd periods and the concentration of zinc in different periods of the experiment showed a significant increase. By raising the expression of transferrin receptors on the surface of tissue cells, selenium enhances the entry of transferrin into the cell by receptor-mediated endocytosis, which reduces the serum iron concentration. On the other hand, iron deficiency affects the production of ceruloplasmin and this protein is responsible for copper transport. Copper changes may have an indirect effect on serum concentrations. The absorption of copper on the intestinal surface is impaired by increasing the synthesis of metallothionein. The use of different sources of selenium caused a continuous supply of selenium and reached the desired level of plasma selenium concentration. The increase in glutathione peroxidase levels is due to a direct correlation between selenium concentration and glutathione peroxidase activity. In general, the use of selenium improves the performance and health of lambs.

کلیدواژه‌ها [English]

  • Selenium
  • Mineral
  • Glutathione peroxidase
  • Superoxide dismutase
  • Fars kaboodeh

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فصلنامه محیط زیست جانوری
دوره 14، شماره 3
آبان 1401
صفحه 43-54

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